Author Archives: Glyn and Liz

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About Glyn and Liz

Writer Liz wainwright and Independent Researcher Glyn Wainwright

Cell Walls – Essential Role of Fats & Cholesterol

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The outer and inner membranes protect and define the cells in the tissues of our bodies. They give them shape and strength. These membranes organise, support and protect the proteins (enzymes) that give function and purpose to the tissues and organs of our bodies.

Cell Membranes are made of fat (lipids) and cholesterol. To work and protect the cell there has to be at least 1 cholesterol molecule for every 4 fat molecules.  Less cholesterol causes the membrane to become weak and leaky.
The maintenance of organs and tissues relies on a regular supply of fats and fat soluble nutrients. This supply comes from the large LDL lipid droplets which are recognised and absorbed by the LDL receptors on the cells. The recycling waste involves the return of smaller HDL  lipid droplets to the liver via the blood stream.

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As we age ours cells LDL receptors can become damaged by sugar leading to poor maintenance of the membranes.  The cell has a shortage of lipids (fats) and cholesterol. Cell walls  becomes leaky and prone to fail. LDL lipids are left unused in the blood stream. HDL lipids are not being returned.

As we age what we we required is a reduction in damage caused by excess blood sugars (glucose and fructose) together with an adequate supply of fats and cholesterol.  

This is the basis of the success of the Low-Carbohydrate High-Fat diets in addressing the modern dietary health issues.

Published research on cell membranes and lipids is at complete odds with modern medical practices and much dietary guidance.  Statins and low fat diets are misguided attempts to prevent fatty nutrients from entering the blood stream by blocking the production of mevalonate.  Mevalonate is used to make steroids hormones, cholesterol, signalling molecules, dolichols and co-enzyme Q10 etc – a whole series of vital health promoting substances.

The Statin-Damage Triad is a modern health crisis progressively brought on by a combination of 3 lifestyle factors: Excess Blood Sugar, Low Dietary Fat intake and statin medications.

Links:  The supporting references to published research are contained in my conference paper  ‘The High-Cholesterol Paradox’ which was especially requested to make facts and history widely accessible.

The Damage Triad: Sugar, Low-Fat and Statins

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There are now countless thousands of statin victims organising self-help groups on the social media sites. They are often frustrated by not finding a formal voice or champion for their concerns within the medical profession.  Fortunately many of them, myself included, are able to research bio-sciences, health and medical matters. The deafening silence of general practice was momentarily broken by Fiona Godley, editor of the BMJ (British Medical Journal) in 2015 and now the story is out there..

Many statin victims find themselves caught up in a triad of life-style damage: Sugar, Low-Fat  and Statin Damage

  1. Elevated blood sugar is damaging organ lipid receptors which capture fatty nutrient parcels called LDL. LDL lipids are no longer able to be absorbed from our blood, leading to a drop in fatty nutrient supply to all the organs and tissues of the body.  The heart, brain, muscles and nervous system are made vulnerable by this shortage of fatty nutrition. The greatest damage is done by fructose reacting with the LDL lipid receptors.
  2. Low-Fat,  or fat restriction, in the diet adds yet more stress to the organs and tissues. They become more deprived of fats and other fat-soluble nutrition. Our cell walls and membranes are a double layer of fats and cholesterol (lipids). The shape, the workings and protection of cell contents rely on this lipid-cholesterol wrapper.  The whole body needs a constant supply of fatty nutrition to maintain the health of all our organs and tissues.
  3.  Statins are defined by their ability to shut down an important biochemical assembly line in our bodies (mevalonate). This blocks vital supplies of cholesterol, hormones, Co-Enzyme Q10 and other signalling molecules in the body. One fifth of all the molecules in cell membranes (walls and dividing) must be cholesterol, and the loss of cholesterol due to statin drugs will eventually cause our cells to leak and fail. Statin victims notice it most in the most used and largest of organs. Muscles begin to leak affecting kidneys. Sufferers talk about “Cola Coloured Urine” which comes from muscle myoglobin (the red stuff out of meat). Eventually the kidneys are blocked by break down products. Cholesterol is required for the formation and function of our memories, thoughts and behaviours! Violence, Dementias and suicides are well documented statin side-effects. The loss of CoQ10 is also debilitating to energy levels and the failure of beta-cells makes statins a significant cause of diabetes.
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The three effects combine to cause a devastating set of circumstances which left unrecognised will lead to kidney failure, dementia and neuro-muscular damage – Life threatening, painful and debilitating conditions.  General practitioners are briefed by the statin manufacturers to see these effects as part of the original reason for prescribing statins.  They are encouraged to prescribe for the side-effects rather than think about their cause. Eventually it is too late to fix the damage. Then what? Pre-mortem or post-mortem?
The cruel irony is that statin related deaths from dementia, kidney disease and organ failure are rarely attributed. They cannot be used in off-set against the relatively insignificant statistical claim that statins may prevent heart attacks!
My associates and I have published reviews in medical journals, and made a conference presentation with references supporting this summary. You can read more in “The High-Cholesterol Paradox” which has references to key journal papers.
Download it free on this link: http://bit.ly/1fkGYgb  Following the link will result in the .pdf being downloaded to your download folder to save or view.

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Thank you for the challenge of putting it simply. We get caught in a
triple jeopardy – Sugar, Low-Fat and Statins. Our Organs are starved of
fatty nutrients. Our cells become leaky and fail. This eventually
progresses via Muscles, Nerves, Central Nervous System to all organs and
tissues. The best way to avoid or mitigate this is to get good Sugar
Control (HbA1c), increase fat nutrition (animal/fish sourced to match
your own fats) and bin the statins. Link to the presentation .pdf – The High-Cholesterol Paradox

Triple Jeopardy – Sugar, Low-Fat & Statins

Why Statins are Toxic

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Statins are technically defined as HMG Co-enzyme A reductase inhibitors.
Inhibiting HMG Co-enzyme A reductase (mevalonate enzyme) has extremely
toxic implications because our cells rely on the products of this
mevalonate synthesis.  Mevalonate, which is the basic building block for
cholesterol, CoQ10, dolichols and all the regulatory steroid hormones
etc…. (see diagram for more) This assembly line is so important
biochemists named it “The Mevalonate Metabolic Pathway” and teach it in
most basic courses.
The statin gamble – to reduce a symptom (not the
cause) i.e. sugar-damaged lipids. It works in that cholesterol
disappears, the lipids disappear, muscles and neurons start to
disappear. The myth pharma seek to exploit is lower LDL without causing
too much obvious toxic damage.
Sugar control will improve lipid
circulation, function and lipid health – without toxic consequences. It
won’t lower vital cholesterol! and raised LDL without sugar-damage
ensures longevity.  
The cholesterol paradox essay link: http://bit.ly/1fkGYgb

The Secret

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lizwainwright:

‘Can you not find somebody else?’
‘No. I’ve got this feeling, Mum, I can’t explain it, but he’s the one.’
‘The Heywood family aren’t our sort.’
‘I know, they’ve got money. But that’s not why I want Dan.’
‘I know it’s not, love, but I hope you’ll change your mind. Geoff Heywood’s all right but Dan’s mother would make your life hell. She’s a Buchanan, and takes after her father. Dan Heywood’s not for you.’
‘He is.’
Doreen Collins was again silent, struggling to make a hard decision.
‘You remember I told you I used to work at Kirkwood House, cleaning for them when you were a baby.’
‘Yeah. So what?’
‘They put the fear of God into me, her family. They wanted nothing to do with us – and she still doesn’t because there’s something I know about the Heywoods.’
‘What?’
‘It’s a secret and you must promise me you won’t tell anyone, ever. Promise.’
So Lynda made that unbreakable promise and listened to the secret that didn’t seem important at the time.

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