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Sugar-Damage & Heart Disease
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Author Archives: Glyn and Liz
Tiny Vessels in the Retina
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Tiny Vessels
Like all organs, our eyes rely on a complex network of blood vessels in order to function properly. Vessels supply blood to the retina, a thin layer of cells in the eye (shown here as pink, blue and red layers) that convert the light we see into electrical signals. If these tiny vessels develop badly, they can block the retina’s cells and cause vision loss. Scientists are studying a type of protein whose job is to keep a close eye on these vessels, and prevent them from growing awry. The team found that abnormal blood vessels were more likely to develop in mice that don’t have this protein in their retinal cells. Regions in their retina where this protein was missing are shown in bright green. This research helps us understand how specific proteins in the eye are there as a safeguard against vascular disease and ultimately, blindness.
Written by Gaelle Coullon
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What are you going to do about Christmas, Lynda?’
‘I don’t know.’
The little furry jacket that she sent for Michael had a hood with cute little ears on top, so he would look like a little bear. She wrapped it carefully in paper with bright Father Christmas figures doing a dance across it, and a few of her tears had hidden themselves in the soft fabric as she’d pictured her one year old grandson wearing it.
She’d enclosed a Christmas card for the family, and had written the ‘sender’ address very clearly on the back of the brown paper parcel. She posted it at the beginning of December, allowing plenty of time for a response.It came back a few days later. Robbie had examined the parcel carefully, and had guessed what it was. He was upset to see Lynda’s face turn white as he handed it to her.
‘It says ‘return to sender’. The post office must have delivered it to the wrong address, love.’
‘Yeah. Thanks.’ She clutched the package to her breast and fled up the stairs to her room
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Why cholesterol drugs might affect memory
Dr Duane Graveline has agreed to share his comments on the article in Scientific American with you:
“When I saw Melinda Moyers’ first mistake I was amused for my morning walk
took place in Island Pond, Vermont not Merritt Island Island, Florida where
I currently reside. It was then I spotted the title “Why cholesterol
drugs might affect memory’ and began to get angry. I had spent 15 years
documenting the cognitive side effects of statin drugs and our FDA’s
Medwatch had recently reported over 7500 statin associated transient
global amnesia and memory loss reports received during the time period
2004-2014. A reasonably accurate title would not read cholesterol
lowering drugs might affect memory. The proper title would read
cholesterol lowering drugs affect memory. If Ms Moyer has done her job
she would know these facts just as I know them so why not use them.
Then
when my name came up again in the article I was surprised to read I
had been “following a healthy diet to keep my cholesterol low.” Never
since my research on the subject have I been even remotely concerned
about my cholesterol. It is irrelevant to heart attack and stroke.
Inflammation is the underlying cause. Many times in my writing I have
told my readers how ashamed I was to have raised my family on no eggs,
skim milk and margarine for 17 years so conned I had been as a much
younger doctor. Had Ms. Moyer but asked me I would have told her this.
And then she topped it off by saying “he says he has never felt better.”
Now I am really angry for she has never in the past decade asked me
and since the year 2000 I have almost completely lost the ability to
walk. I barely make it with cane and walker and am but a moment away
from wheelchair existence. Peripheral neuropathy says my neurologist
with my muscle biopsy showing denervation atrophy (no nerve, no
muscle). Ms Moyer conjured up this entire thing. If she had only called
me.
Duane Graveline MD MPH”
It’s Not Dementia, It’s Your Heart Medication: Cholesterol Drugs and Memory
Cholesterol – look after it!
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What I learned in med school was wrong. Cholesterol / LDL is not the evil culprit despite what pharma/AHA want us to believe.
Conflicting Evidence – A Statin Paradox
We know that all cells (all tissues) cease their exocytosis and endocytosis activity, if the membrane cholesterol content drops by
around 10%. This is easily achieved on statin therapy. Everything slows down.
In the case of bone remodelling both osteoclasts (cutters) and osteoblasts (builders) will reduce their repair activity in bone remodelling.
Calcium loss from bones will be reduced but micro-fracture repairs will not be repaired on statin therapy. Bone density is maintained on statin therapy but the developing micro-fractures weaken the skeleton.
It’s all about what is measured and how long you follow through.
Statin trials can be designed to prove both benefit and detriment to bones.
This is why experimental osteoporosis treatment by statins to maintain bone density ultimately gives way to increased fracture risk.
Two competing bone remodelling processes are failing and conflicting measures can be used to conflict statin safety.
You will find this pattern repeats in damage and repair of myelin in MS studies.
To summarise: Short-term gain- long-term pain on statins
Dr Luca Mascitelli and myself went into this in our review paper 2009 at http://bit.ly/Ob9wKM
Liz & Glyn Wainwright 