Category Archives: General

Cholesterol Drugs & Authority Figures

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it is worrying to think about how subtle changes in senior politicians behaviours may be caused by their medications.

The neurological effects of cholesterol depletion can produce a wide range of mental conditions reported to be associated with serum cholesterol depletion. Depression, violent behaviour, homicidal
behaviour and suicide are all known associates of cholesterol depletion [58, 59]. In a recent study, cholesterol content was measured in cortical and subcortical tissue of brains from 41 male suicide completers and 21 male controls. Violent suicides were found to have lower gray matter cholesterol content overall compared with nonviolent suicides and controls [60]. Randomised trials with statins have not shown a definite association between cholesterol-lowering
treatment and non-illness mortality from suicides, accidents, and violence [61, 62]. However, statin trials are specifically designed to test drug efficacy, often with run-in phases, and investigators usually
conduct the studies in groups of patients who have few comorbidities and are not using many concomitant medications, and when side effects are measured, their seriousness and severity are not graded. Indeed, in clinical practice it has been suggested that severe anger and irritability may occour in some statin users [63].
Neural systems have significant vulnerability to cholesterol depletion. First is the reduction in the synaptic exocytosis and endocytosis of essential signalling lipoproteins; then comes the vulnerability due to the high dependency of myelination on denovo cholesterol biosynthesis.

58. Lester D. Serum cholesterol levels and suicide: a metaanalysis.
Suicide Life Threat Behav 2002; 32: 333-46.
59. Edgar PF, Hooper AJ, Poa NR, Burnett JR. Violent behavior
associated with hypocholesterolemia due to a novel APOB
gene mutation. Mol Psychiatry 2007; 12: 258-63.
60. Lalovic A, Levy E, Luheshi G, et al. Cholesterol content in
brains of suicide completers. Int J Neuropsychopharmacol
2007; 10: 159-66.
61. Muldoon MF, Manuck SB, Mendelsohn AB, Kaplan JR, Belle
SH. Cholesterol reduction and non-illness mortality: metaanalysis
of randomised clinical trials. BMJ 2001; 322: 11-5.
62. Baigent C, Keech A, Kearney PM, et al.; Cholesterol
Treatment Trialists’ (CTT) Collaborators. Efficacy and safety
of cholesterol-lowering treatment: prospective metaanalysis
of data from 90,056 participants in 14
randomised trials of statins. Lancet 2005; 366: 1267-78.
63. Golomb BA, Kane T, Dimsdale JE. Severe irritability
associated with statin cholesterol-lowering drugs. QJM
2004; 97: 229-35.

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I loved this book it grabbed me right from the first words and I couldn’t put it down. The characters are so interesting you need to know what happens to them but at the same time are so familiar you feel you have lived next door to them. I understand this is the first part of a trilogy and I can wait to see what happens to Lynda and her family next.

The Girl who wasn’t Good Enough (The Lynda Collins Trilogy) (Kindle Edition)

 5.0 out of 5 stars Would Reccomend, 27 May 2012 By Bexsox @Amazon

(via lizwainwright)

Source: lizscript.co.uk

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Epidemiological and clinical trial evidence suggests that omega-3 polyunsaturated fatty acids (PUFAs) might have a significant role in the prevention of coronary heart disease. Dietary sources of omega-3 PUFA include fish oils rich in eicosapentaenoic acid and docosahexaenoic acid along with plants rich in alpha-linolenic acid. Randomized clinical trials with fish oils (eicosapentaenoic acid and docosahexaenoic acid) and alpha-linolenic acid have demonstrated reductions in risk that compare favorably with those seen in landmark secondary prevention trials with lipid-lowering drugs. Several mechanisms explaining the cardioprotective effect of omega-3 PUFAs have been suggested, including antiarrhythmic, hypolipidemic, and antithrombotic roles. Although official US guidelines for the dietary intake of omega-3 PUFAs are not available, several international guidelines have been published. Fish is an important source of omega-3 PUFAs in the US diet.

Sockey Salmon. (Photo courtesy of Washington State Department of Fish and Wildlife)

The fats of life: the role of omega-3 fatty acids in the prevention of coronary heart disease.

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Recent efforts by medical journal staffs to improve the quality of research papers have had mixed results. Examples are given to show that randomized, placebocontrolled trials are not free from bias and that the failure to include all-cause death rates can be extremely misleading, as can the use of relative risks in the absence of absolute risks. Other examples show how the conclusions in an abstract may not agree with the data in the body of the paper, or do not tell the whole truth. Still others use false surrogate endpoints or faulty trial protocols to favor a desired outcome. The whole picture may be seen as a breakdown of the peer-review system.  – Joel M. Kauffman, Ph.D.

Bias in Recent Papers on Diets and Drugs in Peer-Reviewed Medical Journals

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On a free promotion on Sunday 23rd (Kindle Time!) Somebody by Liz Wainwright Roy and Eileen have won a holiday, a week at the Carnival in Nice, a second honeymoon – the only trouble is…. they split up six months ago. Original BBC Radio Production was directed by: Marion Nancarrow for BBC Radio 4 Drama. Broadcast 1998. Running Time: 55m Cast: EILEEN: Lynda Bellingham, ROY: David Ross

From the same playwright there is another free BBC Radio Drama script on Smashwords Mr’s Danby’s Destiny – Free Book. Original BBC Broadcast starred Lynda Baron – astrology themed black-comedy
You can find out more about Liz’s plays and novels at Liz’s web pages

Somebody by Liz wainwright – Free Promotion on Sunday 23rd September

Medical Dogma – Fats and Cholesterol

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How did our health authorities miss the role of sugars as the primary cause of age related illness in modern civilization.   There are many reasons why authorities under pressure to debate, judge and decide are confused about the difference between association with causation.   Almost every day we are subject to statistics which are misunderstood.  Although more than 80% of heart attack victims in America are English speaking it is clearly not a cause.  Statistics  can be used to show that  patients travelling to hospital in ambulances have higher morbidities than those travelling by public transport.

The causes of modern diseases have erroneously been attributed to dietary fat and cholesterol.  This erroneous dogma conflicts with the causative evidence that Carbohydrate (Sugar generating foods) are the real issue in modern diets.

AGEs & RAGEs