A sample preview of slides for my presentation is linked here.
Publications on which the talk is based are free to download here.
Tag Archives: cholesterol
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The Bio-chemical Science pages of Glyn Wainwright, Publisher, Independent Reader of Research and Honorary Recording Engineer for Leeds Symphony Orchestra<
Anecdote: A diabetic clinician told me she had noticed that when patients had good control of their hba1c (an indicator of sugar-damage in blood ) their ‘cholesterol’ score also improved.
Every molecule of cholesterol in the body is known to be identical to every other.
The Good/Bad labeling of cholesterol is extremely unscientific and unhelpful, and that is a matter of scientific fact.
How were intelligent, well educated, medical professionals persuaded to popularise this ‘Good ‘ cholesterol versus ’Bad’ cholesterol idea?
The unscientific phrase ‘Bad Cholesterol’ is a misleading description of damage to the ’lipid transport system ‘, whose basic function was described by the Nobel Prize winners James E. Rothman, Randy W. Schekman and Thomas C. Südhof. (Awarded “for their discoveries of machinery regulating vesicle traffic, a major transport system in our cells”.
The lipid transport system is used by the body to deliver essential supplies of fat, cholesterol, and other fat-soluble nutrients.
The lipid transport system is able to repair and recycle, but can be progressively overwhelmed by the damage accumulated over several decades.
This damage to the lipid system is caused by oxidation and glycation: the result of excessive consumption of refined sugars (in particular High Fructose syrups).
It is not ‘bad cholesterol’ but sugar-damage to the proteins that make the lipids available to the organs of our body.
Unconsumed ‘damaged’ ldl in the blood is an indicator of trouble because the organs are being starved of vital fats cholesterol and fat-soluble nutrients.
‘Bad Medicine’ prevents the liver and all other organs from making essential cholesterol indirectly stop the supply of lipids to the blood.
Cholesterol lowering medications have a variety of very broad variety of adverse-effects, all attributable to organs being starved of fat, cholesterol and fat-soluble nutrients.
The ‘bad medicine’s do not tackle the cause of damage to the ldl – lipids supply.
The primary cause of this ldl damage is the oxidation and glycation of the ldl’s components.
The main dietary and lifestyle causes of ldl damage are over-consumption of refined sugars and inactivity.
The reactive sugars like fructose, found in manufactured corn syrups are particularly troublesome, because they directly attach to ldl-protein mechanisms causing a mal-function which starves the organs.
Important protective and anti-oxidant functions rely on Cholesterol and CoQ10 – both of which are reduced anti-cholesterol medications.
The unscientific use of the incorrect description ‘Bad Cholesterol’ has held back medicine for over 40 years and it is time to look at the evidence in more detail:-
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Sweden has become the first Western nation to develop national dietary guidelines that reject the popular low-fat diet dogma in favor of low-carb high-fat nutrition advice.
Some quotes from Prof. Nyström translated into English from Dr. Eenfeldt:
Butter, olive oil, heavy cream, and bacon are not harmful foods. Quite the opposite. Fat is the best thing for those who want to lose weight. And there are no connections between a high fat intake and cardiovascular disease.
On Monday, SBU, the Swedish Council on Health Technology Assessment, dropped a bombshell. After a two-year long inquiry, reviewing 16,000 studies, the report “Dietary Treatment for Obesity” upends the conventional dietary guidelines for obese or diabetic people.
For a long time, the health care system has given the public advice to avoid fat, saturated fat in particular, and calories. A low-carb diet (LCHF – Low Carb High Fat, is actually a Swedish “invention”) has been dismissed as harmful, a humbug and as being a fad diet lacking any scientific basis.
Instead, the health care system has urged diabetics to eat a lot of fruit (=sugar) and low-fat products with considerable amounts of sugar or artificial sweeteners, the latter a dangerous trigger for the sugar-addicted person.
This report turns the current concepts upside down and advocates a low-carbohydrate, high-fat diet, as the most effective weapon against obesity.
The expert committee consisted of ten physicians, and several of them were skeptics to low-carbohydrate diets at the beginning of the investigation.
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Nobelprize.org, The Official Web Site of the Nobel Prize
Congratulation to Rothman, Schekman and Südhof for their Nobel Prize recognising an amazing set of discoveries about machinery regulating vesicle traffic.
What is now remarkable about the mechanism is the role of Cholesterol in facilitating the wrapping and release machinery. In 2008 Xia et al. established that it only took a 10% fall in membrane cholesterol to bring the whole process of vesicle release to a stop. (doi: 10.1210/en.2008-0161)
Cholesterol was so ubiquitous, and very erroneously thought to be a causative agent in disease, its vital roles in vesicle formation and release were overlooked. Now that the vesicles are a hot topic I hope to see cholesterol recognised for its role in all this vesicle traffic.
Sugar Damage and Dementia
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...the risk of mortality or acute coronary syndrome was positively associated with age; male gender; hypertension; uncontrolled diabetes; being a former smoker; HAVING LOW LDL; having low BMI....
Vitamin D Levels for Preventing Acute Coronary
Syndrome and Mortality: Evidence of a Non-Linear
Association
doi: 10.1210/jc.2013-1185
J Clin Endocrinol Metab
Low LDL and low BMI associated with increased mortality risk
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How to make a scare out of very little with statistics:
Enjoy the bacon with eggs – as with all traditional foods.
CBN News has a much more important story to tell!.
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The brain is only 2% of your body mass but it contains 25% of your cholesterol. The cholesterol is vital to memory formation (synapses) and nerve protection (myelin). Our livers make 2.5g of fresh cholesterol every day to replace the losses. The liver delivers the brains fresh daily supply of cholesterol to the brain in small lipid droplets known as LDL. The empties return to the liver known as HDL with various waste products for recycling and disposal.
To get these vital supplies into the brain the LDL droplets have to cross the blood-brain barrier. The particles carry a protein label which is recognised by the receptors. The brains receptors lock onto the LDL and allow the particles to pass though into the brains astrocyte cells. These astrocytes use the cholesterol and fats in the care and feeding of the neurons and all is well with our thoughts and memories.
If we consume a lot of sugary products, especially fructose, the receptors become damaged by sugary attachments and fail to work. The LDL then builds up in the blood and the brain is starved of fat and cholesterol. All is now not well with our thoughts and memories.
This is a simplification of our biochemical papers on this matter. Other organs like the heart are also affected this way. How is it possible for an educated professionals to go on misleading us by referring to LDL as “Bad Cholesterol”?
Fructose is getting away with murder and the blame is being laid upon the good guys – fat and cholesterol.
Please click on and read our free peer reviewed medical journal publications and ask your medical advisors some tough questions about this low cholesterol ‘madness’.
“Cholesterol Lowering Therapies and Membrane Cholesterol”
Wainwright G Mascitelli L & Goldstein M R
Archives of Medical Science Vol. 5 Issue 3 p289-295 2009
“Is the metabolic syndrome caused by a high fructose, and relatively low fat, low cholesterol diet?”
Seneff S, Wainwright G, and Mascitelli L
Archives of Medical Science Vol. 7 Issue 1 p8-20 2011 doi: 10.5114/aoms.2011.20598
“Nutrition and Alzheimer’s disease: the detrimental role of a high carbohydrate diet”
Seneff S., Wainwright G., and Mascitelli L.
European Journal of Internal Medicine 2011 doi:10.1016/j.ejim.2010.12.0172011
Liz & Glyn Wainwright 