A Fructose Damage Blood Test?

HbA1c sugar damaged blood protein – are we measuring the
most important thing.?

Whilst I have no doubt that measuring this is a great way to
detect potential sugar damage, it may only be the tip of the iceberg.

Fructose damage should be measured. Fructose has been
increasing in our foods since the now discredited ‘low-fat high-sugar’ food
fads hit the markets almost 40 years ago.

On a ‘High-Fat Low-Car’ regime I have found that keeping below
70mmol/mol (6%) has prevented all obvious diabetes symptoms from developing.

Avoiding refined Fructose products may be most important
because Fructose is 7x more reactive and damaging towards the bodies protein
mechanisms and enzymes.  The benefits of
avoiding high-fructose foods (HFCS on labels) may be many times greater than
simply managing glucose for modern type 2 diabetics if over the last 40 years HFCS
fructose additives are 7x more dangerous than glucose when it come to sugar damage!

We urgently need
to routinely test for Fructose damage in a blood test!

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Low-Cholesterol – A Leading Cause of Failing Health

Diabetes

In 2008 Dr Luca Mascitelli sent me a paper by Xia et al. [1] which showed how lowering cholesterol could stop insulin production in the human pancreatic beta-cells – a leading cause of diabetes. Here we had a biochemical explanation of the rise in diabetes associated with statin use and the science was excellent.

Adverse-Effects of Cholesterol Lowering

Could low-cholesterol affect other organs of the body?  After a review of published papers in the professional medical journals we had the answer. Yes! Lowering the cholesterol level in the bodies organs (cell membranes) by as little as 10% (molecular ratio) stopped the exchange of nutrients and other products with the blood stream. The organs’ cells shut down and the implications are devastating to health [2].

Muscles – Wastage, Aches, Mobility Issues and Kidney Failure

In muscles the cell walls, becoming deficient in cholesterol, will eventually leak causing muscle loss, mobility problems, ‘cola-coloured urine’ and ultimately kidney failure (muscle waste damaging kidney tubules – rhabdomyolysis).  These effects are warned about in the leaflets that come with statins medications. The connection between the nervous system and the muscles also begins to fail because there is not enough cholesterol, used to wrap the chemical messengers (neurotransmitters Lrp-4 and Agrin) between nerve and muscle causing aches and mobility issues. The heart is the most important muscle and so we could now understand why low cholesterol is associated with progressive heart failure.
See [2] for review details and references.

Central Nervous System

The published work of F W Pfrieger, shows how copious quantities of cholesterol  are used making memories and thought processes. The nerves (neurons) and  connections (synapses) depend on cholesterol for formation and function. The nerve fibres (axons) are protected by myelin (50% cholesterol) which needs constant supply for repair. In our review we discuss a range of problems from Dementias through behavioural change and aggression which are associated with cholesterol depletion and adverse side-effects of statin.
See [2] for review details and references.

Other problems now associated with Low-Cholesterol levels in organs are:
• Raised risk of MRSA and skin infections
• Failure of Bone maintenance (fracture risks)
• Increased Cancer risks
• Increased risk of death associated with falling cholesterol

Cholesterol is vital and the events leading up to this health crisis and contradictory advice from authorities is discussed further in my conference paper report “The High Cholesterol Paradox”

Low-Cholesterol + Elevated Blood Sugars + Statins = Very Poor Health Outcomes

1. Xia F, Xie L, Mihic A, et al. Inhibition of cholesterol biosynthesis impairs insulin secretion and voltage-gated calcium channel function in pancreatic beta-cells. Endocrinology 2008; 149: 5136-45.
2. G Wainwright, L Mascitelli & M Goldstein. Cholesterol-lowering therapy and cell membranes. Stable plaque at the expense of unstable membranes? Arch. Med. Sci. 5, 289–295 (2009).

Specific links to papers and blogs are highlighted in throughout

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Sugar versus Lipids (Fat & Cholesterol)

Cholesterol now deserves a full pardon and should be awarded ‘Freedom of the Body’. We now know cholesterol is (and always was) a hero in all the cells of our bodies. The cell walls are made of fat and cholesterol working together to protect, give shape and function to each cell..So when you seek to lower your cholesterol you can expect some loss of function and ill effects (see http://bit.ly/1LdEqhn for details)

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Statin Damage: We have seen a huge growth in on-line social media groups complaining bitterly the devastating health effects of statin medications. Statins stop an enzyme in the liver from working, depriving the body of vital substances and signalling compounds (Cholesterol, Hormones and Co-Q10 and more). Eventually tissues break down (muscle & neuron loss) and stop communicating (signalling loss).  The adverse effects are well documented and we have some idea of the numbers  from the FDA’s own FAER database. results have been documented. This “Mevalonate Blockade” is basic cellular biochemistry so the question is why is modern medicine unwilling to acknowledge and deal with this statin damage?

Sugar-Damaged Lipids

After 50 years of blaming cholesterol for upsetting our blood lipids it has come as a shock to the medical profession to find that the guilty party is sugars (fructose & glucose). Diabetics and their clinicians are increasingly commenting on the fact that Lipid tests show improvement (LDL/HDL ratio in blood fats) if excess blood sugar is well managed. The most important number a medical check-up can give you is a blood sugar-damage test called HbA1c or A1c. Get this number under control and the LDL/HDL ratio improves along with general health. The reason that good control of blood sugar improves blood lipids is the reduction in damage caused by sugar to the LDL lipid receptors that absorb the lipids into our cells and organs . The blood LDL lipids are responsible for transporting all the fats, fatty nutrients and cholesterol to our organs to ensure they work.  The HDL collects and returns excess fatty substances for recycling.

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So it was sugar that stopped the cycle from working – not cholesterol!

An ultimately lethal combination of excess blood sugar, low-fat diets and statins is doing huge harm among our mature population.

Fortunately many patients abandon statins after a few months of experiencing their effects but some persist believing they owe their lives to the misguided claims that they prevent heart disease. Some pharmaceutical companies fund CPD courses on which Doctors are advised to see the statin side-effects as part of the progression of the diseases the statins are claimed to prevent. Treating statin adverse side-effects adds to profitability and makes good financial sense. This is a poor unethical way for drug for the Pharmaceutical Industry to behave and independent regulatory investigation is urgently required. The problem is finding independent experts who are not ultimately dependent of the system for funding!

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What has changed is the science. Over recent decades evidence was building that blood sugar-damage was damaging the lipid nutrition cycle by attacking the LDL receptor mechanisms.

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Excess Sugar+ Low-Fat+ Statins = Debilitating Deterioration of Organs

Let’s Talk Statins

For over a decade I’ve been reviewing all the research I can find on sugar, fats and cholesterol. This has involved writing review papers in bio-science and medical journals, and presenting at conferences and giving talks. I studied bio-chemistry in the 1960s and revived my interest to look at age related illnesses and related medical issues. This interest was sparked off by a 6 day period of taking statins, and realising very quickly that something was seriously amiss with this ‘preventative’ approach to my health.
I am not clinically trained and do not to advise individuals about their ills. However, I do try to help people, when asked, to become more aware of the biological science and principle behind age related illnesses as we move from maturity to seniority! Three themes keep recurring in this bio-science adventure: sugar damage, low-fat damage and statin damage.
Statin users who ask me questions are often concerned about what they have read and maybe they have started to feel unwell since commencing medication. To those who have no pre-existing illness and are taking statins to keep themselves  well (like I did some years ago) I ask “ Why are you taking a medication that makes you feel unwell and has only a dubious statistical link with reducing heart attacks?”  When I was offered statins I was told there would be a 30% reduction in risk over the next 10 years. I was not told that the absolute risk was in fact reduced from 4% to 3% (1 % reduction compared with 3% produced the dramatic figure 30%). This is not impressive given the real toxicity and documented risks that statins carry! Starting from a position of health, over the 6 days I spent taking on 40mg Simvastatin, I started with 5 new disturbing ailments.  My old 1960s biochemistry books showed these were all likely linked to cholesterol and lipid deficiencies in my body. I stopped taking them and recovered fully within a week. Day 7 is still in the packet which I keep with my notes.

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Sometimes when giving talks I meet a statin user who is convinced that they owe their life to statins . The conviction normally comes straight from their medical advisors, who have been adamant about the claimed benefits. So I become curious about the impact on their general health. Taking care not prejudice them I enquire about general wellness, and listen carefully for comments about muscle aches, exercise tolerance, joints aches etc. Quite often I have collected a list known statin side-effects, which they understand to be “expected at my age”. If spouses are present it can be revealing to get a second slightly less subjective opinion, especially on mood and behavioural changes. The crucial question is how have these things changed since starting statins. Quite often many other medications have been added to deal with what we know to be predictable effects of not only statins but also elevated blood sugar and inadequate amounts of natural fats in the diet.  
If they are healthy or concerned about the statin’s effects I suggest asking their GP for a ‘Statin Holiday’ after which they can assess the impact the statins were having.  A supervised withdrawal might be advisable. A ‘holiday’ can help with in assessing other unpleasant medications too!
Normally I get one of two reactions when talking to medical practitioners. A small minority are too busy to think clearly about it and resent the implied criticism of their prescribing to guidelines. Thankfully the majority of cardiologists and GPs feel informed and are keen to undertake further reading. They’ve often puzzled over the patients’ responses and intolerance toward statins.
All too often the statin toxicity alarm bells do not sound until some permanent harm has accumulated.
(Highlighted links to further materials)

Cell Walls – Essential Role of Fats & Cholesterol

The outer and inner membranes protect and define the cells in the tissues of our bodies. They give them shape and strength. These membranes organise, support and protect the proteins (enzymes) that give function and purpose to the tissues and organs of our bodies.

Cell Membranes are made of fat (lipids) and cholesterol. To work and protect the cell there has to be at least 1 cholesterol molecule for every 4 fat molecules.  Less cholesterol causes the membrane to become weak and leaky.
The maintenance of organs and tissues relies on a regular supply of fats and fat soluble nutrients. This supply comes from the large LDL lipid droplets which are recognised and absorbed by the LDL receptors on the cells. The recycling waste involves the return of smaller HDL  lipid droplets to the liver via the blood stream.

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As we age ours cells LDL receptors can become damaged by sugar leading to poor maintenance of the membranes.  The cell has a shortage of lipids (fats) and cholesterol. Cell walls  becomes leaky and prone to fail. LDL lipids are left unused in the blood stream. HDL lipids are not being returned.

As we age what we we required is a reduction in damage caused by excess blood sugars (glucose and fructose) together with an adequate supply of fats and cholesterol.  

This is the basis of the success of the Low-Carbohydrate High-Fat diets in addressing the modern dietary health issues.

Published research on cell membranes and lipids is at complete odds with modern medical practices and much dietary guidance.  Statins and low fat diets are misguided attempts to prevent fatty nutrients from entering the blood stream by blocking the production of mevalonate.  Mevalonate is used to make steroids hormones, cholesterol, signalling molecules, dolichols and co-enzyme Q10 etc – a whole series of vital health promoting substances.

The Statin-Damage Triad is a modern health crisis progressively brought on by a combination of 3 lifestyle factors: Excess Blood Sugar, Low Dietary Fat intake and statin medications.

Links:  The supporting references to published research are contained in my conference paper  ‘The High-Cholesterol Paradox’ which was especially requested to make facts and history widely accessible.

The Damage Triad: Sugar, Low-Fat and Statins

There are now countless thousands of statin victims organising self-help groups on the social media sites. They are often frustrated by not finding a formal voice or champion for their concerns within the medical profession.  Fortunately many of them, myself included, are able to research bio-sciences, health and medical matters. The deafening silence of general practice was momentarily broken by Fiona Godley, editor of the BMJ (British Medical Journal) in 2015 and now the story is out there..

Many statin victims find themselves caught up in a triad of life-style damage: Sugar, Low-Fat  and Statin Damage

  1. Elevated blood sugar is damaging organ lipid receptors which capture fatty nutrient parcels called LDL. LDL lipids are no longer able to be absorbed from our blood, leading to a drop in fatty nutrient supply to all the organs and tissues of the body.  The heart, brain, muscles and nervous system are made vulnerable by this shortage of fatty nutrition. The greatest damage is done by fructose reacting with the LDL lipid receptors.
  2. Low-Fat,  or fat restriction, in the diet adds yet more stress to the organs and tissues. They become more deprived of fats and other fat-soluble nutrition. Our cell walls and membranes are a double layer of fats and cholesterol (lipids). The shape, the workings and protection of cell contents rely on this lipid-cholesterol wrapper.  The whole body needs a constant supply of fatty nutrition to maintain the health of all our organs and tissues.
  3.  Statins are defined by their ability to shut down an important biochemical assembly line in our bodies (mevalonate). This blocks vital supplies of cholesterol, hormones, Co-Enzyme Q10 and other signalling molecules in the body. One fifth of all the molecules in cell membranes (walls and dividing) must be cholesterol, and the loss of cholesterol due to statin drugs will eventually cause our cells to leak and fail. Statin victims notice it most in the most used and largest of organs. Muscles begin to leak affecting kidneys. Sufferers talk about “Cola Coloured Urine” which comes from muscle myoglobin (the red stuff out of meat). Eventually the kidneys are blocked by break down products. Cholesterol is required for the formation and function of our memories, thoughts and behaviours! Violence, Dementias and suicides are well documented statin side-effects. The loss of CoQ10 is also debilitating to energy levels and the failure of beta-cells makes statins a significant cause of diabetes.
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The three effects combine to cause a devastating set of circumstances which left unrecognised will lead to kidney failure, dementia and neuro-muscular damage – Life threatening, painful and debilitating conditions.  General practitioners are briefed by the statin manufacturers to see these effects as part of the original reason for prescribing statins.  They are encouraged to prescribe for the side-effects rather than think about their cause. Eventually it is too late to fix the damage. Then what? Pre-mortem or post-mortem?
The cruel irony is that statin related deaths from dementia, kidney disease and organ failure are rarely attributed. They cannot be used in off-set against the relatively insignificant statistical claim that statins may prevent heart attacks!
My associates and I have published reviews in medical journals, and made a conference presentation with references supporting this summary. You can read more in “The High-Cholesterol Paradox” which has references to key journal papers.
Download it free on this link: http://bit.ly/1fkGYgb  Following the link will result in the .pdf being downloaded to your download folder to save or view.

Link

Thank you for the challenge of putting it simply. We get caught in a
triple jeopardy – Sugar, Low-Fat and Statins. Our Organs are starved of
fatty nutrients. Our cells become leaky and fail. This eventually
progresses via Muscles, Nerves, Central Nervous System to all organs and
tissues. The best way to avoid or mitigate this is to get good Sugar
Control (HbA1c), increase fat nutrition (animal/fish sourced to match
your own fats) and bin the statins. Link to the presentation .pdf – The High-Cholesterol Paradox

Triple Jeopardy – Sugar, Low-Fat & Statins

Why Statins are Toxic

Statins are technically defined as HMG Co-enzyme A reductase inhibitors.
Inhibiting HMG Co-enzyme A reductase (mevalonate enzyme) has extremely
toxic implications because our cells rely on the products of this
mevalonate synthesis.  Mevalonate, which is the basic building block for
cholesterol, CoQ10, dolichols and all the regulatory steroid hormones
etc…. (see diagram for more) This assembly line is so important
biochemists named it “The Mevalonate Metabolic Pathway” and teach it in
most basic courses.
The statin gamble – to reduce a symptom (not the
cause) i.e. sugar-damaged lipids. It works in that cholesterol
disappears, the lipids disappear, muscles and neurons start to
disappear. The myth pharma seek to exploit is lower LDL without causing
too much obvious toxic damage.
Sugar control will improve lipid
circulation, function and lipid health – without toxic consequences. It
won’t lower vital cholesterol! and raised LDL without sugar-damage
ensures longevity.  
The cholesterol paradox essay link: http://bit.ly/1fkGYgb