Tag Archives: glucose

Autoimmunity and T2D

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My anecdotal experience and studies have shown me thIs:-

Glycoproteins are important on cell surfaces (extracellular matrix) they are anchored by dolichols and form an important part of the communication between tissue and immune system, with recognisable sequences of sugars deliberately assembled for the matrix. This is structural sugars in the body assembled by enzymes in the normal cellular machinery.

Glycation damaged proteins (AGE). These are exposed proteins who randomly become attached to a mono-sugar (usually glucose but recently increasingly fructose) attaching to lysine by the maillard reaction).

In cooking at oven temps this is a desirable and flavoursome reaction at some speed.

In diabetics this is a very slow (decades at body temp) degradation of lipid receptor mechanisms, elastins and collagens.

Auto-immunes and T2D

The body has a clean-up immune response to random AGE mono-sugar attack, which is overwhelmed as we age and develop T2D (over decades). The suagr damage effect is present in many tissues showing a strong immune response (arthritis, eczema) which often respond well to carbohydrate restriction and increased dietary use of ‘essential fatty acids’.

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Oxidative Stress

One way is the damage caused by reactive oxygen species (ROS) that are produced by the burning of blood sugar (Glucose) and oxygen in our cells to  produce energy. The free radicals produced by this can cause oxidation damage to surrounding tissues (oxidative stress). The body uses a variety of anti-oxidants (e.g. cholesterol & CoQ10) to control or limit such damage but these can be overwhelmed.  The rate of damage may exceed the rate of repair with excessive use of energy from sugar.

Source: lizscript.co.uk