The interest in this video has been amazing and thank you to all who have watched it all. You don’t have to because those with less time here are the “bite-sized” topic-based links below.
Seneff S, Wainwright G, Mascitelli L. Review paper Is the metabolic syndrome caused by a high fructose, and relatively low fat, low cholesterol diet?. Archives of Medical Science. 2011;7(1):8-20. doi:10.5114/aoms.2011.20598
Low-carbohydrate
high-fat (LCHF) diets are at least as effective as other dietary
strategies for reducing body weight, with the additional advantage of
increased satiety and spontaneous reduction in energy intake.
LCHF
diets are an effective dietary strategy to improve glycaemic control
and reduce hyperinsulinaemia in type 2 diabetes mellitus and in
otherwise healthy patients with insulin resistance.
LCHF
diets have unique effects on blood lipid concentrations and
cardiovascular risk factors, characterised by decreased blood TG, ApoB
and saturated fat concentrations, reduced small LDL particle numbers and
increased HDL-C concentrations. The effect on LDL-C concentrations is
variable.
In 2008 Dr Luca Mascitelli sent me a paper by Xia et al. [1] which showed how lowering cholesterol could stop insulin production in the human pancreatic beta-cells – a leading cause of diabetes. Here we had a biochemical explanation of the rise in diabetes associated with statin use and the science was excellent.
Adverse-Effects of Cholesterol Lowering
Could low-cholesterol affect other organs of the body? After a review of published papers in the professional medical journals we had the answer. Yes! Lowering the cholesterol level in the bodies organs (cell membranes) by as little as 10% (molecular ratio) stopped the exchange of nutrients and other products with the blood stream. The organs’ cells shut down and the implications are devastating to health [2].
Muscles – Wastage, Aches, Mobility Issues and Kidney Failure
In muscles the cell walls, becoming deficient in cholesterol, will eventually leak causing muscle loss, mobility problems, ‘cola-coloured urine’ and ultimately kidney failure (muscle waste damaging kidney tubules – rhabdomyolysis). These effects are warned about in the leaflets that come with statins medications. The connection between the nervous system and the muscles also begins to fail because there is not enough cholesterol, used to wrap the chemical messengers (neurotransmitters Lrp-4 and Agrin) between nerve and muscle causing aches and mobility issues. The heart is the most important muscle and so we could now understand why low cholesterol is associated with progressive heart failure. See [2] for review details and references.
Central Nervous System
The published work of F W Pfrieger, shows how copious quantities of cholesterol are used making memories and thought processes. The nerves (neurons) and connections (synapses) depend on cholesterol for formation and function. The nerve fibres (axons) are protected by myelin (50% cholesterol) which needs constant supply for repair. In our review we discuss a range of problems from Dementias through behavioural change and aggression which are associated with cholesterol depletion and adverse side-effects of statin. See [2] for review details and references.
Other problems now associated with Low-Cholesterol levels in organs are: • Raised risk of MRSA and skin infections • Failure of Bone maintenance (fracture risks) • Increased Cancer risks • Increased risk of death associated with falling cholesterol
Cholesterol now deserves a full pardon and should be awarded ‘Freedom of the Body’. We now know cholesterol is (and always was) a hero in all the cells of our bodies. The cell walls are made of fat and cholesterol working together to protect, give shape and function to each cell..So when you seek to lower your cholesterol you can expect some loss of function and ill effects (see http://bit.ly/1LdEqhn for details)
Statin Damage: We have seen a huge growth in on-line social media groups complaining bitterly the devastating health effects of statin medications. Statins stop an enzyme in the liver from working, depriving the body of vital substances and signalling compounds (Cholesterol, Hormones and Co-Q10 and more). Eventually tissues break down (muscle & neuron loss) and stop communicating (signalling loss). The adverse effects are well documented and we have some idea of the numbers from the FDA’s own FAER database. results have been documented. This “Mevalonate Blockade” is basic cellular biochemistry so the question is why is modern medicine unwilling to acknowledge and deal with this statin damage?
Fortunately many patients abandon statins after a few months of experiencing their effects but some persist believing they owe their lives to the misguided claims that they prevent heart disease. Some pharmaceutical companies fund CPD courses on which Doctors are advised to see the statin side-effects as part of the progression of the diseases the statins are claimed to prevent. Treating statin adverse side-effects adds to profitability and makes good financial sense. This is a poor unethical way for drug for the Pharmaceutical Industry to behave and independent regulatory investigation is urgently required. The problem is finding independent experts who are not ultimately dependent of the system for funding!
What has changed is the science. Over recent decades evidence was building that blood sugar-damage was damaging the lipid nutrition cycle by attacking the LDL receptor mechanisms.
Excess Sugar+ Low-Fat+ Statins = Debilitating Deterioration of Organs
The outer and inner membranes protect and define the cells in the tissues of our bodies. They give them shape and strength. These membranes organise, support and protect the proteins (enzymes) that give function and purpose to the tissues and organs of our bodies.
Cell Membranes are made of fat (lipids) and cholesterol. To work and protect the cell there has to be at least 1 cholesterol molecule for every 4 fat molecules. Less cholesterol causes the membrane to become weak and leaky. The maintenance of organs and tissues relies on a regular supply of fats and fat soluble nutrients. This supply comes from the large LDL lipid droplets which are recognised and absorbed by the LDL receptors on the cells. The recycling waste involves the return of smaller HDL lipid droplets to the liver via the blood stream.
As we age ours cells LDL receptors can become damaged by sugar leading to poor maintenance of the membranes. The cell has a shortage of lipids (fats) and cholesterol. Cell walls becomes leaky and prone to fail. LDL lipids are left unused in the blood stream. HDL lipids are not being returned.
As we age what we we required is a reduction in damage caused by excess blood sugars (glucose and fructose) together with an adequate supply of fats and cholesterol.
This is the basis of the success of the Low-Carbohydrate High-Fat diets in addressing the modern dietary health issues.
The Statin-Damage Triad is a modern health crisis progressively brought on by a combination of 3 lifestyle factors: Excess Blood Sugar, Low Dietary Fat intake and statin medications.