Link Fructose is the most potent inhibitor (after cholesterol) of copper utilization discovered, to date. It has been known since the 30s that copper deficiency impairs glucose tolerance; Metabolic interactions among dietary cholesterol, copper, and fructose doi:10.1152/ajpendo.00591.2009 Leslie M. KlevayDepartments of Internal Medicine and of Pharmacology, Physiology, and Therapeutics, University of North Dakota, School of Medicine and Health Sciences, Grand Forks, North Dakota Global High Fructose Corn Syrup Use May Be Fueling Diabetes Increase