Submission to the Academy of Medical Royal Colleges on the causes the recent rise in obesity.
Tag Archives: nutrition
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The inability of current recommendations to control the epidemic of diabetes, the specific failure of the prevailing low-fat diets to improve obesity, cardiovascular risk or general health and the persistent reports of some serious side effects of commonly prescribed diabetic medications, in combination with the continued success of low-carbohydrate diets in the treatment of diabetes and metabolic syndrome without significant side effects, point to the need for a reappraisal of dietary guidelines.
•They present major evidence for low-carbohydrate diets as first approach for diabetes.•Such diets reliably reduce high blood glucose, the most salient feature of diabetes.•Benefits do not require weight loss although nothing is better for weight reduction.•Carbohydrate-restricted diets reduce or eliminate medication.
•There are no side effects comparable to those seen in intensive treatment with drugs.
Feinman RD, Pogozelski WK, Astrup A, Bernstein RK, Fine EJ, Westman EC, Accurso A, Frasetto L, McFarlane S, Nielsen JV, Krarup T, Gower BA, Saslow L, Roth KS, Vernon MC, Volek JS, Wilshire GB, Dahlqvist A, Sundberg R, Childers A, Morrison K, Manninen AH, Dashti H, Wood RJ, Wortman J, Worm N, Dietary Carbohydrate restriction as the first approach in diabetes management. Critical review and evidence base, Nutrition (2014), doi: 10.1016/j.nut.2014.06.011.
You can’t get funding very easily for lifestyle trials because there is no profit to be made. Or is there? Medical Insurance and NHS costs would be reduced dramatically – so there is a cost reduction motive for funding!
Dietary Carbohydrate restriction as the first approach in diabetes management
The ‘High Cholesterol’ Paradox
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The Bio-chemical Science pages of Glyn Wainwright, Publisher, Independent Reader of Research and Honorary Recording Engineer for Leeds Symphony Orchestra<
Anecdote: A diabetic clinician told me she had noticed that when patients had good control of their hba1c (an indicator of sugar-damage in blood ) their ‘cholesterol’ score also improved.
Every molecule of cholesterol in the body is known to be identical to every other.
The Good/Bad labeling of cholesterol is extremely unscientific and unhelpful, and that is a matter of scientific fact.
How were intelligent, well educated, medical professionals persuaded to popularise this ‘Good ‘ cholesterol versus ’Bad’ cholesterol idea?
The unscientific phrase ‘Bad Cholesterol’ is a misleading description of damage to the ’lipid transport system ‘, whose basic function was described by the Nobel Prize winners James E. Rothman, Randy W. Schekman and Thomas C. Südhof. (Awarded “for their discoveries of machinery regulating vesicle traffic, a major transport system in our cells”.
The lipid transport system is used by the body to deliver essential supplies of fat, cholesterol, and other fat-soluble nutrients.
The lipid transport system is able to repair and recycle, but can be progressively overwhelmed by the damage accumulated over several decades.
This damage to the lipid system is caused by oxidation and glycation: the result of excessive consumption of refined sugars (in particular High Fructose syrups).
It is not ‘bad cholesterol’ but sugar-damage to the proteins that make the lipids available to the organs of our body.
Unconsumed ‘damaged’ ldl in the blood is an indicator of trouble because the organs are being starved of vital fats cholesterol and fat-soluble nutrients.
‘Bad Medicine’ prevents the liver and all other organs from making essential cholesterol indirectly stop the supply of lipids to the blood.
Cholesterol lowering medications have a variety of very broad variety of adverse-effects, all attributable to organs being starved of fat, cholesterol and fat-soluble nutrients.
The ‘bad medicine’s do not tackle the cause of damage to the ldl – lipids supply.
The primary cause of this ldl damage is the oxidation and glycation of the ldl’s components.
The main dietary and lifestyle causes of ldl damage are over-consumption of refined sugars and inactivity.
The reactive sugars like fructose, found in manufactured corn syrups are particularly troublesome, because they directly attach to ldl-protein mechanisms causing a mal-function which starves the organs.
Important protective and anti-oxidant functions rely on Cholesterol and CoQ10 – both of which are reduced anti-cholesterol medications.
The unscientific use of the incorrect description ‘Bad Cholesterol’ has held back medicine for over 40 years and it is time to look at the evidence in more detail:-
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Key points in our paper are:-
The amyloid-β present in Alzheimer’s plaque may not be causal,
since drug-induced suppression of its synthesis led to further
cognitive decline in the controlled studies performed so far.
• Researchers have identified mitochondrial dysfunction and brain
insulin resistance as early indicators of Alzheimer’s disease.
• ApoE-4 is a risk factor for Alzheimer’s disease, and ApoE is involved
in the transport of cholesterol and fats, which are essential for signal
transduction and protection from oxidative damage.
• The cerebrospinal fluid of Alzheimer’s brains is deficient in fats and
cholesterol.
• Advanced glycation end-products (AGEs) are present in significant
amounts in Alzheimer’s brains.
• Fructose, an increasingly pervasive sweetening agent, is ten times as
reactive as glucose in inducing AGEs.
• Astrocytes play an important role in providing fat and cholesterol to
neurons.
• Glycation damage interferes with the LDL-mediated delivery of fats
and cholesterol to astrocytes, and therefore, indirectly, to neurons.
• ApoE induces synthesis of Aβ when lipid supply is deficient.
• Aβ redirects neuron metabolism towards other substrates besides
glucose, by interferingwith glucose and oxygen supply and increasing
bioavailability of lactate and ketone bodies.
• Synthesis of the neurotransmitter, glutamate, is increased when
cholesterol is deficient, and glutamate is a potent oxidizing agent.
• Over time, neurons become severely damaged due to chronic exposure
to glucose and oxidizing agents, and are programmed for apoptosis
due to highly impaired function.
• Once sufficiently many neurons are destroyed, cognitive decline is
manifested.
• Simple dietary modification, towards fewer highly-processed
carbohydrates and relatively more fats and cholesterol, is likely a
protective measure against Alzheimer’s disease.
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Cholesterol
Vitamin D3
Spot the difference Cholesterol + sunlight -> Vitamin D3
Visit Dr Stephanie Seneff’s blog essay for the full story
– Eat a low-fat diet,
– Avoid the damaging rays of the sunThese two tenets, taken together, are extremely bad medical advice, and that the consequences of our government’s success in selling this well-intended but misguided recommendation to the American public are devastating and long-lasting, particularly to our nation’s children.
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Earlier this year I attended a the London WAPF conference in support of Dr Stephanie Seneff and we were fortunate enough to meet Dr Natasha Campbell-McBride. Once Dr Natasha C-M explains what happens to the food you eat and how it affects your health you are empowered to improve your health. She asks you to consider the community that lives within us digesting our food and protecting us from infection and harm. Once you understand your symbiotic relationship with this microbial community you will respect it, nurture it and take much greater care of what you put in your mouth.
e.g. If food manufacturers treat food to extend its shelf-life (the spoilage bugs can’t survive on it) you have to consider what that does to your internal community of microbial friends when you eat it!
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“A great book that shatters so many of the nutritional fantasies and fads of the last twenty years. Read it and prolong your life.”
Clarissa Dickson Wright.
Clarissa Dickson Wright.
Liz & Glyn Wainwright 