Link Fat Chance: Beating the odds against sugar, processed food, obesity, and disease by Robert H. Lustig In Fat Chance, Lustig argues that the rise of obesity is the result of high concentrations of insulin in the blood, together with resistance to leptin – a hormone secreted by the body’s fat cells that normally signals the brain to shut down food intake. “Is the metabolic syndrome caused by a high fructose, and relatively low fat, low cholesterol diet?” Seneff S,. Wainwright G., and Mascitelli L.DOI: 10.5114/aoms.2011.20598 Archives of Medical Science Vol. 7 2011 ( Yes it is! ) Obesity epidemic caused by too much sugar?