AGEs (Advanced Glycaemic End-products)

The other cause of sugar damage is the uncontrolled (non-enzymic) attachment of excess sugar molecules (e.g. fructose and glucose) to proteins (such as collagen, elastin and receptors) around the body.  Over time this gives rise to sugar-damaged proteins known as appropriately as Advanced Glycaemic End-products (AGEs). These AGEs cause, joints, arteries, heart, lungs and skin etc. to lose their elasticity.

The transport of the fat soluble nutrients (including vitamins A, D & E )  to all the organs of the body rely upon Lipids (fatty droplets) produced by the liver and circulating in the blood in the blood.   A simplified version of this mechanism has the liver sending large particles (LDL) to deliver the nutrients and the tissues returning smaller particles (HDL) for recycling.  The particles have apolipoproteins (APO) as labels  the to identify their destination and purpose. Matching receptors are deployed on tissues to latch onto the lipids droplets they require.   When the labels and receptors are damaged by attached sugars, the tissues cannot get the fats they require and the fats are scavenged by visceral fat cells in the abdomen.  This causes a cascade leading to a variety of AGE related diseases as we age.