Sugar versus Lipids (Fat & Cholesterol)

Cholesterol now deserves a full pardon and should be awarded ‘Freedom of the Body’. We now know cholesterol is (and always was) a hero in all the cells of our bodies. The cell walls are made of fat and cholesterol working together to protect, give shape and function to each cell..So when you seek to lower your cholesterol you can expect some loss of function and ill effects (see http://bit.ly/1LdEqhn for details)

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Statin Damage: We have seen a huge growth in on-line social media groups complaining bitterly the devastating health effects of statin medications. Statins stop an enzyme in the liver from working, depriving the body of vital substances and signalling compounds (Cholesterol, Hormones and Co-Q10 and more). Eventually tissues break down (muscle & neuron loss) and stop communicating (signalling loss).  The adverse effects are well documented and we have some idea of the numbers  from the FDA’s own FAER database. results have been documented. This “Mevalonate Blockade” is basic cellular biochemistry so the question is why is modern medicine unwilling to acknowledge and deal with this statin damage?

Sugar-Damaged Lipids

After 50 years of blaming cholesterol for upsetting our blood lipids it has come as a shock to the medical profession to find that the guilty party is sugars (fructose & glucose). Diabetics and their clinicians are increasingly commenting on the fact that Lipid tests show improvement (LDL/HDL ratio in blood fats) if excess blood sugar is well managed. The most important number a medical check-up can give you is a blood sugar-damage test called HbA1c or A1c. Get this number under control and the LDL/HDL ratio improves along with general health. The reason that good control of blood sugar improves blood lipids is the reduction in damage caused by sugar to the LDL lipid receptors that absorb the lipids into our cells and organs . The blood LDL lipids are responsible for transporting all the fats, fatty nutrients and cholesterol to our organs to ensure they work.  The HDL collects and returns excess fatty substances for recycling.

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So it was sugar that stopped the cycle from working – not cholesterol!

An ultimately lethal combination of excess blood sugar, low-fat diets and statins is doing huge harm among our mature population.

Fortunately many patients abandon statins after a few months of experiencing their effects but some persist believing they owe their lives to the misguided claims that they prevent heart disease. Some pharmaceutical companies fund CPD courses on which Doctors are advised to see the statin side-effects as part of the progression of the diseases the statins are claimed to prevent. Treating statin adverse side-effects adds to profitability and makes good financial sense. This is a poor unethical way for drug for the Pharmaceutical Industry to behave and independent regulatory investigation is urgently required. The problem is finding independent experts who are not ultimately dependent of the system for funding!

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What has changed is the science. Over recent decades evidence was building that blood sugar-damage was damaging the lipid nutrition cycle by attacking the LDL receptor mechanisms.

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Excess Sugar+ Low-Fat+ Statins = Debilitating Deterioration of Organs

Let’s Talk Statins

For over a decade I’ve been reviewing all the research I can find on sugar, fats and cholesterol. This has involved writing review papers in bio-science and medical journals, and presenting at conferences and giving talks. I studied bio-chemistry in the 1960s and revived my interest to look at age related illnesses and related medical issues. This interest was sparked off by a 6 day period of taking statins, and realising very quickly that something was seriously amiss with this ‘preventative’ approach to my health.
I am not clinically trained and do not to advise individuals about their ills. However, I do try to help people, when asked, to become more aware of the biological science and principle behind age related illnesses as we move from maturity to seniority! Three themes keep recurring in this bio-science adventure: sugar damage, low-fat damage and statin damage.
Statin users who ask me questions are often concerned about what they have read and maybe they have started to feel unwell since commencing medication. To those who have no pre-existing illness and are taking statins to keep themselves  well (like I did some years ago) I ask “ Why are you taking a medication that makes you feel unwell and has only a dubious statistical link with reducing heart attacks?”  When I was offered statins I was told there would be a 30% reduction in risk over the next 10 years. I was not told that the absolute risk was in fact reduced from 4% to 3% (1 % reduction compared with 3% produced the dramatic figure 30%). This is not impressive given the real toxicity and documented risks that statins carry! Starting from a position of health, over the 6 days I spent taking on 40mg Simvastatin, I started with 5 new disturbing ailments.  My old 1960s biochemistry books showed these were all likely linked to cholesterol and lipid deficiencies in my body. I stopped taking them and recovered fully within a week. Day 7 is still in the packet which I keep with my notes.

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Sometimes when giving talks I meet a statin user who is convinced that they owe their life to statins . The conviction normally comes straight from their medical advisors, who have been adamant about the claimed benefits. So I become curious about the impact on their general health. Taking care not prejudice them I enquire about general wellness, and listen carefully for comments about muscle aches, exercise tolerance, joints aches etc. Quite often I have collected a list known statin side-effects, which they understand to be “expected at my age”. If spouses are present it can be revealing to get a second slightly less subjective opinion, especially on mood and behavioural changes. The crucial question is how have these things changed since starting statins. Quite often many other medications have been added to deal with what we know to be predictable effects of not only statins but also elevated blood sugar and inadequate amounts of natural fats in the diet.  
If they are healthy or concerned about the statin’s effects I suggest asking their GP for a ‘Statin Holiday’ after which they can assess the impact the statins were having.  A supervised withdrawal might be advisable. A ‘holiday’ can help with in assessing other unpleasant medications too!
Normally I get one of two reactions when talking to medical practitioners. A small minority are too busy to think clearly about it and resent the implied criticism of their prescribing to guidelines. Thankfully the majority of cardiologists and GPs feel informed and are keen to undertake further reading. They’ve often puzzled over the patients’ responses and intolerance toward statins.
All too often the statin toxicity alarm bells do not sound until some permanent harm has accumulated.
(Highlighted links to further materials)

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Statins increase life expectancy in short-term trials, but not by very much. There are questions about the accuracy of trial results and the safety of statins in the long-term is not established. The cost-effectiveness of statins is also poor and the cost to the NHS for all those currently being suggested as needing them would be crippling.

Until a considerable amount of better evidence is available that demonstrate statins do have real, long-term benefits without serious adverse side effects, it might be wise to restrict their use to patients at very high risk.

Barry Groves on the work of Dr Uffe Ravnskov and statistician Al Lohse.Why do Placebos appear to kill?

Statins: Saviours of Mankind or Expensive Scam?

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Statins for all? (BMJ Extract)
An epidemiologist’s call for all healthy adults over 50 to take statins was uncritically reinforced by the media without proper discussion of side effects. A problem for primary care doctors is that even rare side effects become common when millions of low risk patients are treated with statins……………………….As for evidence that high risk patients are deciding not to take statins because of a perceived risk of side e‹ ects, this seems to be based on anecdote, and my own anecdote is also that many patients decline to take statins, saying that the side effects are unacceptable.
The arguments for giving statins to a whole population need to be made equally in forms of absolute risk; we must be fair about potential side effects, including the association with diabetes; and crucially we must also be clear that improving population health should not simply
be made the work of drug companies.

Margaret McCartney general practitioner, Glasgow
References are in the version on bmj.com.
BMJ 2012;345:e6044