Extracts of my contribution to the book by Dr Duane Gravelins MD
Tag Archives: statins
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Cholesterol – under attack again – by vaccine!
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Thank you |Stephanie for the acknowledgements and refs in this amazing essay on statins
Statins and Myoglobin: How Muscle Pain and Weakness Progress to Heart, Lung and Kidney Failure
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Low-Cholesterol – A Leading Cause of Failing Health
Diabetes
In 2008 Dr Luca Mascitelli sent me a paper by Xia et al. [1] which showed how lowering cholesterol could stop insulin production in the human pancreatic beta-cells – a leading cause of diabetes. Here we had a biochemical explanation of the rise in diabetes associated with statin use and the science was excellent.
Adverse-Effects of Cholesterol Lowering
Could low-cholesterol affect other organs of the body? After a review of published papers in the professional medical journals we had the answer. Yes! Lowering the cholesterol level in the bodies organs (cell membranes) by as little as 10% (molecular ratio) stopped the exchange of nutrients and other products with the blood stream. The organs’ cells shut down and the implications are devastating to health [2].
Muscles – Wastage, Aches, Mobility Issues and Kidney Failure
In muscles the cell walls, becoming deficient in cholesterol, will eventually leak causing muscle loss, mobility problems, ‘cola-coloured urine’ and ultimately kidney failure (muscle waste damaging kidney tubules – rhabdomyolysis). These effects are warned about in the leaflets that come with statins medications. The connection between the nervous system and the muscles also begins to fail because there is not enough cholesterol, used to wrap the chemical messengers (neurotransmitters Lrp-4 and Agrin) between nerve and muscle causing aches and mobility issues. The heart is the most important muscle and so we could now understand why low cholesterol is associated with progressive heart failure.
See [2] for review details and references.
Central Nervous System
The published work of F W Pfrieger, shows how copious quantities of cholesterol are used making memories and thought processes. The nerves (neurons) and connections (synapses) depend on cholesterol for formation and function. The nerve fibres (axons) are protected by myelin (50% cholesterol) which needs constant supply for repair. In our review we discuss a range of problems from Dementias through behavioural change and aggression which are associated with cholesterol depletion and adverse side-effects of statin.
See [2] for review details and references.
Other problems now associated with Low-Cholesterol levels in organs are:
• Raised risk of MRSA and skin infections
• Failure of Bone maintenance (fracture risks)
• Increased Cancer risks
• Increased risk of death associated with falling cholesterol
Low-Cholesterol + Elevated Blood Sugars + Statins = Very Poor Health Outcomes
1. Xia F, Xie L, Mihic A, et al. Inhibition of cholesterol biosynthesis impairs insulin secretion and voltage-gated calcium channel function in pancreatic beta-cells. Endocrinology 2008; 149: 5136-45.
2. G Wainwright, L Mascitelli & M Goldstein. Cholesterol-lowering therapy and cell membranes. Stable plaque at the expense of unstable membranes? Arch. Med. Sci. 5, 289–295 (2009).
Specific links to papers and blogs are highlighted in throughout

Let’s Talk Statins
For over a decade I’ve been reviewing all the research I can find on sugar, fats and cholesterol. This has involved writing review papers in bio-science and medical journals, and presenting at conferences and giving talks. I studied bio-chemistry in the 1960s and revived my interest to look at age related illnesses and related medical issues. This interest was sparked off by a 6 day period of taking statins, and realising very quickly that something was seriously amiss with this ‘preventative’ approach to my health.
I am not clinically trained and do not to advise individuals about their ills. However, I do try to help people, when asked, to become more aware of the biological science and principle behind age related illnesses as we move from maturity to seniority! Three themes keep recurring in this bio-science adventure: sugar damage, low-fat damage and statin damage.
Statin users who ask me questions are often concerned about what they have read and maybe they have started to feel unwell since commencing medication. To those who have no pre-existing illness and are taking statins to keep themselves well (like I did some years ago) I ask “ Why are you taking a medication that makes you feel unwell and has only a dubious statistical link with reducing heart attacks?” When I was offered statins I was told there would be a 30% reduction in risk over the next 10 years. I was not told that the absolute risk was in fact reduced from 4% to 3% (1 % reduction compared with 3% produced the dramatic figure 30%). This is not impressive given the real toxicity and documented risks that statins carry! Starting from a position of health, over the 6 days I spent taking on 40mg Simvastatin, I started with 5 new disturbing ailments. My old 1960s biochemistry books showed these were all likely linked to cholesterol and lipid deficiencies in my body. I stopped taking them and recovered fully within a week. Day 7 is still in the packet which I keep with my notes.

Sometimes when giving talks I meet a statin user who is convinced that they owe their life to statins . The conviction normally comes straight from their medical advisors, who have been adamant about the claimed benefits. So I become curious about the impact on their general health. Taking care not prejudice them I enquire about general wellness, and listen carefully for comments about muscle aches, exercise tolerance, joints aches etc. Quite often I have collected a list known statin side-effects, which they understand to be “expected at my age”. If spouses are present it can be revealing to get a second slightly less subjective opinion, especially on mood and behavioural changes. The crucial question is how have these things changed since starting statins. Quite often many other medications have been added to deal with what we know to be predictable effects of not only statins but also elevated blood sugar and inadequate amounts of natural fats in the diet.
If they are healthy or concerned about the statin’s effects I suggest asking their GP for a ‘Statin Holiday’ after which they can assess the impact the statins were having. A supervised withdrawal might be advisable. A ‘holiday’ can help with in assessing other unpleasant medications too!
Normally I get one of two reactions when talking to medical practitioners. A small minority are too busy to think clearly about it and resent the implied criticism of their prescribing to guidelines. Thankfully the majority of cardiologists and GPs feel informed and are keen to undertake further reading. They’ve often puzzled over the patients’ responses and intolerance toward statins.
All too often the statin toxicity alarm bells do not sound until some permanent harm has accumulated.
(Highlighted links to further materials)
Cell Walls – Essential Role of Fats & Cholesterol
The outer and inner membranes protect and define the cells in the tissues of our bodies. They give them shape and strength. These membranes organise, support and protect the proteins (enzymes) that give function and purpose to the tissues and organs of our bodies.
Cell Membranes are made of fat (lipids) and cholesterol. To work and protect the cell there has to be at least 1 cholesterol molecule for every 4 fat molecules. Less cholesterol causes the membrane to become weak and leaky.
The maintenance of organs and tissues relies on a regular supply of fats and fat soluble nutrients. This supply comes from the large LDL lipid droplets which are recognised and absorbed by the LDL receptors on the cells. The recycling waste involves the return of smaller HDL lipid droplets to the liver via the blood stream.

As we age ours cells LDL receptors can become damaged by sugar leading to poor maintenance of the membranes. The cell has a shortage of lipids (fats) and cholesterol. Cell walls becomes leaky and prone to fail. LDL lipids are left unused in the blood stream. HDL lipids are not being returned.
As we age what we we required is a reduction in damage caused by excess blood sugars (glucose and fructose) together with an adequate supply of fats and cholesterol.
This is the basis of the success of the Low-Carbohydrate High-Fat diets in addressing the modern dietary health issues.
Published research on cell membranes and lipids is at complete odds with modern medical practices and much dietary guidance. Statins and low fat diets are misguided attempts to prevent fatty nutrients from entering the blood stream by blocking the production of mevalonate. Mevalonate is used to make steroids hormones, cholesterol, signalling molecules, dolichols and co-enzyme Q10 etc – a whole series of vital health promoting substances.
The Statin-Damage Triad is a modern health crisis progressively brought on by a combination of 3 lifestyle factors: Excess Blood Sugar, Low Dietary Fat intake and statin medications.
The Damage Triad: Sugar, Low-Fat and Statins
Many statin victims find themselves caught up in a triad of life-style damage: Sugar, Low-Fat and Statin Damage
- Elevated blood sugar is damaging organ lipid receptors which capture fatty nutrient parcels called LDL. LDL lipids are no longer able to be absorbed from our blood, leading to a drop in fatty nutrient supply to all the organs and tissues of the body. The heart, brain, muscles and nervous system are made vulnerable by this shortage of fatty nutrition. The greatest damage is done by fructose reacting with the LDL lipid receptors.
- Low-Fat, or fat restriction, in the diet adds yet more stress to the organs and tissues. They become more deprived of fats and other fat-soluble nutrition. Our cell walls and membranes are a double layer of fats and cholesterol (lipids). The shape, the workings and protection of cell contents rely on this lipid-cholesterol wrapper. The whole body needs a constant supply of fatty nutrition to maintain the health of all our organs and tissues.
- Statins are defined by their ability to shut down an important biochemical assembly line in our bodies (mevalonate). This blocks vital supplies of cholesterol, hormones, Co-Enzyme Q10 and other signalling molecules in the body. One fifth of all the molecules in cell membranes (walls and dividing) must be cholesterol, and the loss of cholesterol due to statin drugs will eventually cause our cells to leak and fail. Statin victims notice it most in the most used and largest of organs. Muscles begin to leak affecting kidneys. Sufferers talk about “Cola Coloured Urine” which comes from muscle myoglobin (the red stuff out of meat). Eventually the kidneys are blocked by break down products. Cholesterol is required for the formation and function of our memories, thoughts and behaviours! Violence, Dementias and suicides are well documented statin side-effects. The loss of CoQ10 is also debilitating to energy levels and the failure of beta-cells makes statins a significant cause of diabetes.


