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Link to slideshow

Excess exposure to fructose intake determines the liver to metabolize high doses of fructose, producing increased levels of fructose end products, like glyceraldehyde and dihydroxyacetone phosphate, that can converge with the glycolytic pathway. Fructose also leads to increased levels of advanced glycation end products.

The macrophages exposed to advanced glycation end products become  dysfunctional and, on entry into the artery wall, contribute to plaque formation and thrombosis.

Sugar-Damaged Proteins

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In the original study

Among the participants with diabetes, the proportion of glycated haemoglobin at 24 months decreased by 0.4±1.3% in the low-fat group, 0.5±1.1% in the Mediterranean-diet group, and 0.9±0.8% in the low-carbohydrate group. The changes were significant (P<0.05) only in the low-carbohydrate group (P=0.45 for the comparison among groups).

A four year follow up concluded

…a 2-year workplace intervention trial involving healthy dietary changes had long-lasting, favourable post-intervention effects, particularly among participants receiving the Mediterranean and low-carbohydrate diets, despite a partial regain of weight.

Mediterranean and low-carbohydrate diets

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Ever since I read Medical Myths by Joel Kauffman, I have had trouble believing that treating Blood Pressure with one of 5 different chemicals did anything to address the cause of raised blood pressure. Blood pressure is raised by glycation of arterial proteins (Sugar-Damage) how does a pill other than maybe metformin address that?  Lo-Carb Hi-Fat LCHF will address that issue eventually but best not get glycated to start with!

The Independent.ie said today:-

At least 800,000 deaths may have been caused worldwide in the past decade by preventive drugs which are routinely given to patients undergoing surgery to reduce the risk of heart attacks, researchers said yesterday.

And the source of this story is here

“Even if only 10 per cent of doctors followed the guidelines, and that is a conservative estimate, 100 million patients would have been given beta blockers during surgery in the past decade. On the basis of our findings, that means 800,000 would have died prematurely and 500,000 would have suffered a stroke. If our findings are true, that is death on the scale of a world war.” Devereaux P J Associate Professor, Department of Clinical Epidemiology and Biostatistics  Mc Master University

Beta blockers cost more lives than they save!

Immunity & The Complement System

Neutrophils, Monocytes, Mast Cells, Macrophages, Dendritic Cells, B Cells, T Cells

If germs get through the body’s physical and chemical barriers into he bloodstream, a mixture of liquid proteins called complement is activated and attacks them. The complement system includes a series of proteins. While there are millions of different antibodies in your blood stream, each sensitive to a specific antigen, there are only a handful of proteins in the complement system. They float freely in your blood. Complements are manufactured in the liver. The complement proteins are activated by and work with (complement) the antibodies. They cause lysing (bursting) of cells and signal to phagocytes that a cell needs to be removed.

quoted from My-Immunity follow the link (click here)

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The question I have is: If the questions below are based on real concerns about statins –  Can they possibly be safe to use in the Heart Muscles? The answer right now has to be NO. Not until someone proves statins are beneficial in some way and do not mess with vital cell membrane cholesterol and the huge amounts of neural cholesterol we require to function.This has to be more than a misjudged statistical association. This links to a free article by Parker & Thompson in

Exercise & Sport Sciences Reviews:October 2012 – Volume 40 – Issue 4
p 188–194 doi: 10.1097/JES.0b013e31826c169e

Statins are effective in reducing low-density lipoprotein cholesterol and cardiac events but can produce muscle side effects. We have hypothesized that statin-related muscle complaints are exacerbated by exercise and influenced by factors including mitochondrial dysfunction, membrane disruption, and/or calcium handling. The interaction between statins, exercise, and muscle symptoms may be more effectively diagnosed and treated as rigorous scientific studies accumulate.

Why are researchers forced to make a positive statement about Statins before going on to describe how damaging and dangerous they can be? Notice that this paper limits that to acknowledgement of their ability to block cholesterol production. It is rare now to see any direct claim of benefits. I digress…..

Schematic


Questions about Statins and Skeletal Muscle Damage in Sports

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The authors’ findings suggest that higher levels of cholesterol are associated with a better outcome in the early phase after ischemic stroke.

Neurology. 2000 May 23;54(10):1944-9.

Department of Neurology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.

Better outcome in ischemic stroke with high cholesterol.

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More bad news for piles up for statins.

Compared to the individuals not taking statins, those taking statins had higher prevalence of risk factors and obstructive CAD……

Compared to individuals not on statin therapy, individuals who were taking statins were older and had higher body mass index (BMI), risk factors, lower LDL ….& lower HDL….

Statin use was associated with a higher frequency of severe coronary artery stenoses as well as numbers of coronary vessels with obstructive coronary artery disease. Further, statin use was associated with a differentially increased prevalence and extent of mixed-plaque and calcified plaque but not non-calcified plaque.

….the use of statins was associatedwith……..increasing presence and numbers of coronary segments with calcified plaque components.

Many references to contradictions in previous studies and use the word ‘surrogate’ seem to suggest that those who determine medical protocols are going to have problems coming to terms with these disturbing findings.

Statin use is associated with an increased prevalence and extent of coronary plaques possessing calcium.

Statins use and coronary artery plaque composition

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There has been recent speculation about the benefits of blood letting in Type 2 diabetes. However in 2008 L. Mascitelli, F. Pezzetta, M. R. Goldstein wrote

…dietary factors, which inhibit iron absorption (i.e. low-fat dairy consumption and habitual coffee intake), have been shown to be associated with a substantially lower risk of type 2 diabetes

They went on to conclude that a few basic lifestyle interventions might make more sense……

…we suggest that, in patients with or at high risk for type 2 diabetes, improving insulin sensitivity with physical exercise, metformin therapy and low-carbohydrate diet might break the vicious circle of insulin resistance, increased intestinal iron absorption and further worsening of insulin resistance.

Iron and type 2 diabetes – Lifestyle Fixes?

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...the enduring quest for cholesterol lowering in humans in order to reduce cardiovascular risk may have unsuspected side effects. They may not be relevant for the majority of patients, and are therefore not reported in large statin trials, but may lead to adverse effects in patients with an underlying susceptibility to hematological disorders.

Membrane bilipid


Our own review concludes a minimum of 20% molecular cholesterol is functionally important in all cell types.

The cholesterol content of the erythrocyte membrane

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Dr Mary Vernon, MD, is one of the world’s foremost experts on treating obesity and diabetes with low carbohydrate nutrition. She is a practicing family physician, educates doctors on low carb and is active in and former president of the American Society of Bariatric Physicians (doctors specializing in treating obese patients).