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Epidemiological and clinical trial evidence suggests that omega-3 polyunsaturated fatty acids (PUFAs) might have a significant role in the prevention of coronary heart disease. Dietary sources of omega-3 PUFA include fish oils rich in eicosapentaenoic acid and docosahexaenoic acid along with plants rich in alpha-linolenic acid. Randomized clinical trials with fish oils (eicosapentaenoic acid and docosahexaenoic acid) and alpha-linolenic acid have demonstrated reductions in risk that compare favorably with those seen in landmark secondary prevention trials with lipid-lowering drugs. Several mechanisms explaining the cardioprotective effect of omega-3 PUFAs have been suggested, including antiarrhythmic, hypolipidemic, and antithrombotic roles. Although official US guidelines for the dietary intake of omega-3 PUFAs are not available, several international guidelines have been published. Fish is an important source of omega-3 PUFAs in the US diet.

Sockey Salmon. (Photo courtesy of Washington State Department of Fish and Wildlife)

The fats of life: the role of omega-3 fatty acids in the prevention of coronary heart disease.

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Recent efforts by medical journal staffs to improve the quality of research papers have had mixed results. Examples are given to show that randomized, placebocontrolled trials are not free from bias and that the failure to include all-cause death rates can be extremely misleading, as can the use of relative risks in the absence of absolute risks. Other examples show how the conclusions in an abstract may not agree with the data in the body of the paper, or do not tell the whole truth. Still others use false surrogate endpoints or faulty trial protocols to favor a desired outcome. The whole picture may be seen as a breakdown of the peer-review system.  – Joel M. Kauffman, Ph.D.

Bias in Recent Papers on Diets and Drugs in Peer-Reviewed Medical Journals

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On a free promotion on Sunday 23rd (Kindle Time!) Somebody by Liz Wainwright Roy and Eileen have won a holiday, a week at the Carnival in Nice, a second honeymoon – the only trouble is…. they split up six months ago. Original BBC Radio Production was directed by: Marion Nancarrow for BBC Radio 4 Drama. Broadcast 1998. Running Time: 55m Cast: EILEEN: Lynda Bellingham, ROY: David Ross

From the same playwright there is another free BBC Radio Drama script on Smashwords Mr’s Danby’s Destiny – Free Book. Original BBC Broadcast starred Lynda Baron – astrology themed black-comedy
You can find out more about Liz’s plays and novels at Liz’s web pages

Somebody by Liz wainwright – Free Promotion on Sunday 23rd September